Pakiranje i cijena

Sastav po kapsuli

aktivirani zeolit klinoptilolit 300mg

Boswellia sacra 100mg

celuloza vege kapsule 90mg

Namjena

adsorbens teških metala, amonijaka i drugih toksina iz gastrointestinalnog trakta, preventivna i suportivna medicinska terapija

Doziranje

2 kapsule 3 puta dnevno

dnevne doze uzimati s dosta vode neposredno prije jela

uz kemoterapiju pauzirati 3 dana, počevši jedan dan prije kemoterapije i dan nakon kemoterapije

Karakteristike prirodnih supstanci u sastavu

zeolit klinoptilolit

vidi "zeolit u medicini" i "reference"

boswellia sacra ( sveta biljka)

pomaže kod reumatskih oboljenja, crohnove bolesti, ulcerative colitisa, osteoarthritisa, upale dišnih putova, pluća i kronične astme, inducira apoptozu kod različitih tumorskih staničnih linija, prevenira cerebralnu ishemiju, traume mozga i alzheimerovu bolesti, psihoaktivni lijek, učinkovita je kod hepatitisa, dijabetesa, u prevenciji ateroskleroze

Sinergijsko djelovanje i prednosti

PANACEO^med Weihrauch – kronične upalne bolesti (crijevne i reumatske), tumorske i kožne bolesti

U PANACEO^med Weihrauch pored svih priznatih ljekovitih svojstava, zeolit je ujedno nosač fitofarmakološke supstance Boswellia Sacra čija su antiupalna i antitumorska ljekovita svojstva potvrđena u velikom broju znanstvenih i kliničkih studija, te s kojom na staničnoj razini ostvaruje ljekovito sinergističko djelovanje.

Boswellija sacra ima antiinflamantorno djelovanje, pomaže kod bronhijalne astme, problema pluća i dišnih putova, kronične upale crijeva - colitis ulcerosa, crohnove bolesti, candide, kod reumatskih oboljenja, reumatoidnog artritisa, osteoartritisa, brojnih tumorskih oboljenja, kod leukemije, kod edema koje izazivaju tumori mozga, kod hepatitisa, dijabetesa, u prevenciji ateroskleroze, kod problema kože i kontaktnog alergijskog dermatitisa, a ublažava anksioznost i depresiju. Dokazana je opravdanost primjene Boswellie Sacre u prevenciji i liječenju cerebralne ishemije, traume mozga i Alzheimerove bolesti. Boswellia Sacra očito nije samo orijentalni miris nego i lijek budućnosti.

Biljka Boswellia Sacra

Iz smole Boswellie Sacre milenijima se proizvodi tamjan kao orijentalni miris u crkvama, ali i više od toga. Poznato je da tamjan pored ugodnog mirisa ima dezodorirajuće i dezinfekcijsko djelovanje. U Antici je tamjan bio podjednako skup kao i zlato. Od Antike do Srednjeg vijeka liječnici su koristili tamjan kao lijek protiv prehlade i želučanih tegoba. Aryurvedski liječnici tvrde da se Boswellia Sacra već tisućama godina koristi kao biljni lijek tradicionalne indijske medicine za liječenje upalnih stanja kao što su artritis, astma i kolitis.

U Europi su medicinari i farmaceuti otkrili djelovanje tamjana na zdravlje prije 20-ak godina. Farmaceut Manfred Schubert Zsilavecz sa Sveučilišta Johanna Wolfganga Goethea iz Frankfurta tvrdi: "Bosvelijske kiseline su pentaciklički triterpeni, dakle prirodne tvari s kiselim osobinama. Upravo ti sastojci su, čini se, odgovorni za brojna medicinska područja primjene: to su reumatska oboljenja ili kronične upale crijeva kao colitis ulcerosa, te kod candide."

Suvremena znanost je istraživala Boswelliu Sacru najprije kao terapiju kod kroničnih upalnih oboljenja kao što su Crohnova bolest, ulcerative colitis, i osteoarthritis. Inicijalne studije su bile kod Crohnove bolesti kod koje su postignuti vrlo ohrabrujući rezultati. U brojnim dvostruko slijepim studijama Boswellia Sacra je istraživana kod pacijenata s osteoarthritisom. Iako se općenito vjeruje da osteoartritis nije upala, studije su pokazale da je Boswellia sacra blokirala enzime koji doprinose upalama, te da također inhibira enzime koji razgrađuju hrskavicu i kolagen, što uzrokuje bol. Boswellia poboljšava dotok krvi u zglobove, te se zaključno pacijenti već u roku sedam dana značajno bolje osjećaju, te imaju signifikantno blaže simptome i tegobe artritisa.

Glavna aktivna supstanca Boswellična kiselina inducira apoptozu (programirana smrt stanice), pa pokazuje in vitro antiproliferativne efekte kod različitih tumorskih staničnih linija, posebno kod melanoma, tumora mozga glioblastoma, karcinoma jetre, kod leukemije i drugih karcinoma. Pacijentima također olakšava patnje bez nuspojava. U studiji koju je u ožujku 2009 publicirao University of Oklahoma Health Sciences Center navodi se da "Boswellia sacra razlikuje kancerogenu stanicu od normalne stanice, da suzbija razvoj kancerogene stanice, odnosno da inducira specifične citotoksične tumorske stanice."

Studije su pokazale opravdanost primjene Boswellie Sacre kao terapije kod upale dišnih putova, problema pluća i posebno kod kronične astme. Boswellia se ne primjenjuje kao terapija za ublažavanje akutnih astmatičnih napada, nego isključivo kod kronične astme.

Dokazana je opravdanost korištenje Boswellie Sacre, kao fiziološki prihvatljive za proizvodnju lijeka za prevenciju i liječenje cerebralne ishemije, traume mozga i Alzheimerove bolesti.

U svibnju 2008 američki FASEB Journal je objavio da su Johns Hopkins University i Hebrew University of Jerusalem utvrdili da je Boswellia Sacra psyhoaktivni lijek i da ublažava depresiju i anxioznost. Istraživanja su pokazala da je Boswelična kiselina odgovorna i za te efekte. Dokazana je njena učinkovitost kod hepatitisa, dijabetesa, u prevenciji ateroskleroze.

Study

1. Use of incense or hydrogenation products for preventing and/or treating a cerebral ischemia and/or cerebral traumatic lesion

2. Boswellia Serrata and Standard Treatment or Standard Treatment Alone in Treating Patients Who Have Undergone Surgery and Radiation Therapy for Newly Diagnosed or Recurrent High-Grade Glioma

3. Treatment of actinic keratoses with a new olibanum extract

Clinical Trials

4. Update of prior Cochrane evidence-based reviews of interventions for treating collagenous colitis found that clinical improvement was noted in 44% of patients who received active treatment with Boswellia serrata extract compared to 27% of patients who received placebo (n=31; p=0.32). Chande 2005

5. In a study conducted in humans to determine its optimal dosing and safety, Boswellia serrata extract was found to be a safe and well tolerated drug on oral administration in treatment of inflammatory diseases. Sharma 2004

6. 30 patients with osteoarthritis of knee, 15 each receiving active Boswellia serrata extract or placebo for eight weeks were assessed. Patients receiving drug treatment reported decrease in knee pain, increased knee flexion and increased walking distance. Kimmatkar 2003

7. Out of 83 patients with Crohn's disease 44 treated with H15 and 39 treated with mesalazine. Crohn Disease Activity Index between the status of enrolment and end of therapy after treatment with H15 was reduced by 90 and after therapy with mesalazine by 53 scores in the mean.[Article in German]. Gerhardt 2001

8. Twenty patients with chronic colitis were given a preparation of the gum resin of Boswellia serrata (900 mg daily divided in three doses for 6 weeks). 18 patients showed an improvement in more than one of the parameters, including stool properties and histopathology. Gupta 2001

9. Bronchial asthma was reduced in 70% of 40 patients treated with gum resin at 300 mg thrice daily for 6 weeks in a double-blind trial Gupta 1998

10. Usage of NSAIDs declined 5.8% in the Boswellia group vs. 3.1% in the placebo group but no other benefit was noted in a study with 78 rheumatoid arthritis out-patients taking 9 tablets (3600 mg) Boswellia or placebo daily. Sander 1998

11. Ulcerative colitis (where leukotrienes have been implicated) was put into remission for 82% of the Boswellia gum resin (350 mg thrice daily) group vs. 75% of the sulfasalazine (1 g thrice daily) group after 6 weeks. Gupta 1997

12. Osteoarthritic pain and disability were reduced by a mixture of Withania somnifera roots, Boswellia serrata stem, Curcuma longa rhizomes and a zinc complex in a double-blind trial with 42 patients. Kulkarni 1991

13. Observational Studies/Case Reports

14. Limited controlled evidence indicating efficacy of traditional Chinese medicines, aloe vera gel, wheat grass juice, Boswellia serrata and bovine colostrum enemas in ulcerative colitis revealed. Langmead 2006

15. Two cases of therapy with frankincense and myrrh in children. Michie 1991

Traditional and Folk Use

16. Boswellia serrata extracts were used by 36% of patients with inflammatory bowel disease in a survey conducted. Joos 2006

17. Evidance from different excavations revealed that record of frankincense use is 300 years ahead of the existing record shown.[Article in Chinese]. Zhang 2001

18. Salai Guggal - Boswellia serrata: from a herbal medicine to a non-redox inhibitor of leukotriene biosynthesis. Ammon 1996

19. Gold, frankincense, myrrh, and medicine. Greene 1993

20. Of five plants in use by Kuwaiti diabetics only myrrh and aloe gums increased glucose tolerance in both normal and diabetic rats while gum Olibanum, Nigella sativa seeds and gum Assafoetida were without effect. Al-Awadi 1987

21. Frankincense and myrrh. Miller 1968

Adverse Effects & Toxicity

22. Allergic contact dermatitis from Boswellia serrata extract in a naturopathic cream.] Acebo 2004

Animal Studies

23. Evaluation of 17 compounds of Boswellia carteri and their inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation (1mug/ear) in mice, explained. Banno 2006

24. The anti-arthritic effects of a Boswellia carterii extract when studied and compared to vehicle control in a Lewis rat adjuvant arthritis model showed significant anti-arthritic and anti-inflammatiory effects. Fan 2005

25. Boswellia carterii produces significant antihyperalgesia and anti-inflammation effects and the antihyperalgesia may be mediated by suppressed inflammation-induced Fos expression in the spinal dorsal horn neurons in rats. Fan 2005a

26. Histological changes in the lung of Wistar albino rats (Rattus norvegicus) after exposure to Arabian incense (genus Boswellia) described. Alokail 2004

27. Reduction of severity and resolution of typical clinical signs, such as intermittent lameness, local pain and stiff gait, were reported after 6 weeks in 29 dogs administered resin extract of Boswellia serrata (BSB108, product of Bogar AG) at a dose of 400 mg/10 kg body weight. Reichling 2004

28. Boswellia serrata extract, containing 60% acetyl 11-keto beta boswellic acid (AKBA), when evaluated for antianaphylactic and mast cell stabilizing activity inhibited the passive paw anaphylaxis reaction in rats in dose-dependant manner. Pungle 2003

29. Pretreatment of aqueous extracts of Zyrulina (Spirulina), Aswagandha (Withania) and Nopane (Boswellia) on colchicine induced chromosome damage showed weakness of clastogenic activity in Swiss albino mice. Ghoshal 2001

30. Boswellia extract or AKBA significantly reduces macroscopic and microcirculatory inflammatory features normally associated with indomethacin administration, in Sprague-Dawley rats. Krieglstein 2001

31. Paw inflammation induced by papaya latex is alleviated by boswellic acids whereas no benefit was seen in the carrageenan model. Gupta 1994

32. Carrageenan-induced rat paw edema was reduced by four species of the plant family Burseraceae, Boswellia dalzielli, Boswellia carteri (gum olibanum), Commiphora mukul and Commiphora incisa. Duwiejua 1993

33. Proliferation of HL-60 cells was inhibited by Bc-4 from Boswellia carterii at 5-10 micrograms/ml. Growth of HL-60 cells in mice was inhibited by Bc-4 at 50 mg/kg. Jing 1992

34. Hepatic gluconeogenesis decrease appears to be the mechanism of blood glucose lowering by Nigella sativa, Myrrh, Gum Olibanum, Gum Asafoetida and Aloe in streptozotocin diabetic rats. al-Awadi 1991

35. Protection by boswellic acids against galactosamine/endotoxin-induced hepatitis in mice. Safayhi 1991

36. Glycosaminoglycan content in rats was decreased in the ketoprofen-treated group but unaltered in the boswellic acids or salai guggal treated groups. Reddy 1989

37. Leucocytes of BSA-induced arthritis in rabbits decreased by boswellic acids (25, 50 and 100 mg/kg/day). Sharma 1989

38. Antibody production and cellular responses to sheep red blood cells in mice was inhibited by Boswellia ethanolic extract. Sharma 1988

39. Arthritis associated elevation of urinary hydroxyproline (free, total, nondialysable and dialysable), hexosamine and uronic acid was slightly decreased in the acute phase and significantly decreased in the chronic phase by boswellic acids in rats. Kesava 1987

40. Arthritis associated elevation of beta-glucuronidase is reduced by boswellic acids or salai-guggal. Kesava 1987

41. Carrageenan or dextran induced edema and formaldehayde induced arthritis were reduced by Boswellia extract. It lacked any analgesic or anti-pyretic effects and no significant effect was seen on cardiovascular, respiratory and central nervous systems. Singh 1986

Pharmacodynamics

42. Study on effect of semisynthetic form of acetyl-11-keto-beta-boswellic acid demonstrated anti-inflammatory effect and indicated that P-selectin-mediated recruitment of inflammatory cells is a major site of action in murine colitis induced by dextran sodium sulfate. Anthoni 2006

43. Boswellia serrata gum resin extract depressed electrically-, acetylcholine-, and barium chloride-induced contractions in the isolated guinea-pig ileum, explaining efficacy of this Ayurvedic remedy in reducing diarrhoea in patients with inflammatory bowel disease. Borrelli 2006

44. The methanol extracts of Boswellia ameero, Boswellia elongata, Buxus hildebrandtii, Cissus hamaderohensis, Cleome socotrana, Dracaena cinnabari, Exacum affine, Jatropha unicostata and Kalanchoe farinacea showed anti-influenza virus type A activity. Mothana 2006

45. Kalanchoe farinacea, Boswellia elongata and Cissus hamaderohensis inhibited all three enzymes: angiotensin converting enzyme, neutral endopeptidase and aminopeptidase N when methanolic extracts of 20 medicinal plants were tested. Oleski 2006

46. Acetyl-11-keto-beta-boswellic acid a pentacyclic terpenoid of Boswellia serrata enhances apoptosis induced by cytokines and chemotherapeutic agents, inhibits invasion, and suppresses osteoclastogenesis through inhibition of NF-kappaB-regulated gene expression. Takada 2006

47. Importance of Boswellic acids, the main active ingredients of BOSWELLIA SERRATA in the treatment of peritumoural oedema and chronic inflammatory diseases discussed and increasing evidence for the importance of transporters, especially P-glycoprotein revealed. Weber 2006

48. The natural products with anti-inflammatory activity including curcumin, parthenolide, cucurbitacins, 1,8-cineole, pseudopterosins, lyprinol, bromelain, flavonoids, saponins, marine sponge natural products and Boswellia serrata gum resin were reviewed. Youn 2006

49. Purified mixture of Boswellic acids from Boswellia carterii plant resin exhibits carrier-dependent immunomodulatory properties in vitro. Cheverier 2005

50. Water extract of Boswellia serrata possesses strong hypocholesterolemic property along with increase in serum HDL revealed by inhibition of lipopolysaccharide induced nitric oxide production by the activated rat peritoneal macrophages. Pandey 2005

51. BHUx polyherbal formulation (5 herbal extracts including boswellia serrata) acts as a potent natural antioxidant, by reduction of key inflammatory mediators of arachidonic acid cascade and by preventing 15-LOX-mediated LDL oxidations, to prevent atherosclerosis. Tripathi 2004

52. 11-keto-BAs might function as potent activators of PMNL by stimulation of MAPK and mobilization of intracellular Ca(2+). Altmann 2002

53. Boswellic acids inhibit the leukotriene biosynthesis in neutrophilic granulocytes by inhibition of 5-lipoxygenase & elastase in leukocytes, to inhibit proliferation,induce apoptosis & to inhibit topoisomerases of leukoma- & glioma cell lines.[Article in German]. Ammon 2002

54. Effect of Boswellia serrata gum resin containing boswellic acids, in terms of cytotoxic, cytostatic & apoptotic activity on five leukemia (HL-60, K 562, U937, MOLT-4, THP-1)& 2 brain tumor(LN-18, LN-229) cell lines expressed in GI50 was more potent than pure 3-O-acetyl-11-keto-beta-boswellic acid. Hostanska 2002

55. Beta-boswellic acid and keto-beta-boswellic acid have antiproliferative and apoptotic effects mediated via a pathway dependent on caspase-8 activation but independent of Fas/FasL interaction in human HT-29 cells. Liu 2002a

56. Boswellic acids have anti-proliferation and anti-cancer effects on Hep G2 cells and the apoptotic effect is mediated by a pathway dependent on caspase-8 activation. Liu 2002b

57. Acetyl-11-keto-beta-boswellic acid inhibits the phosphorylation of extracellular signal-regulated kinase 1 and 2 in meningioma cells stimulated with platelet-derived growth factor BB by interrupting signaling of pathway. Park 2002a

58. Treatment of meningioma AKBA revealed potent cytotoxic activity with half-maximal inhibitory concentrations in range of 2 - 8 microM by inhibiting phosphorylation of Erk-1/2 and impairing the motility of meningioma cells stimulated with platelet-derived growth factor BB. Park 2002b

59. Tetracyclic triterpene 3-oxo-tirucallic acid contributes significantly to the overall biological effects of B. serrata resin. Boden 2001

60. Boswellia serrata affects the interleukin-4 (IL-4), IL-5, IL-6, IL-9, IL-10, and IL-13, which stimulate the growth, differentiation, and recruitment of mast cells, basophils, eosinophils, and B-cells, all of which are involved in humoral immunity, inflammation, and the allergic response. Miller 2001

61. Apoptosis of leukemia cells is increased by acetyl-11-keto-beta-boswellic acid (AKBA) but not by amyrin, a structural analog without effect on 5-lipoxygenase (EC 1.13.11.34). DNA laddering and PCR indicates inhibition of topoisomerase I. Hoernlein 1999

62. Boswellic acid acetate at 12.5 microg/ml (24.2 microM) from Boswellia carterii Birdw induces differentiation of myeloid leukemia HL-60, U937 and ML-1 cells but not erythroid leukemia DS-19 and K562 cells. 20 microg/ml killed 60% of all cells at 24 h. Jing 1999

63. Apoptosis observed in leukemia cell line HL60 and bone marrow leukemic cells from 30 acute non-lymphocytic leukemic (ANLL) patients on treatment with Boswellia Carterii Birdw. [Article in Chinese]. Qi 1999

64. Acetyl-11-keto-beta-boswellic acid (AKBA) inhibition of 5-lipoxygenase (EC 1.13.11.34) is allosteric (non competitive) and calcium dependent. Sailer 1998

65. 3-O-acetyl-11-keto-beta-boswellic acid inhibited DNA, RNA and protein synthesis in HL-60 cells with IC50 = 0.6, 0.5, and 4.1 microM, respectively, and inhibited cell growth but not viability. Shao 1998

66. Nonredox type 5-lipoxygenase inhibitors generally are activated by glutathione or dithiothreitol. However, no such redox-dependent effects were observed with acetyl-11-keto-beta-boswellic acid. Werz 1998

67. Leukotrienes B4 and C4 from ionophore stimulated PMNLs wre inhibited by (IC50 in microgm/ml) acetylboswellic acids (IC50=8.5), 11-keto-beta-boswellic acid (IC50=3), or MK 886 (IC50=0.0068). Wildfeuer 1998

68. Contracture of sketal muscle and inhibition of the twitch response to nerve stimulation was seen with essential oils of clary sage, dill, fennel, frankincense and nutmeg. Lis-Balchin 1997

69. Human leukocyte elastase is inhibited by acetyl-11-keto-beta-boswellic acid (IC50 = 15 microM), beta-boswellic acid, amyrin and ursolic acid, but not by 18beta-glycyrrhetinic acid. Ursolic acid and amyrin do not inhibit 5-lipoxygenase. Safayhi 1997

70. 5-Lipoxygenase inhibition requires the 11-keto and a hydrophilic group on C4 of ring A of boswellic analogs. Potency of AKBA was only slightly diminished by deacetylation or by reduction of the carboxyl to alcohol. It is inhibited by amyrin. Sailer 1996

71. 5-lipoxygenase (EC 1.13.11.34) inhibition by AKBA is reduced by noninhibitory pentacyclic triterpenes, concentration-dependently. This isn't due to nonspecific lipophilic interactions, because cholesterol, cortisone, testosterone (4 rings) lack effect. Safayhi 1995

72. Review of anticancer plants with emphasis on Boswellia, Indigofera, Camptotheca, Curcuma, Iris, Ginseng, Cephalotaxus and Taxus. Han 1994

73. Frankincense essential oil (Boswellia carterii Birdwood) exhibited a strong immunostimulant activity when assessed by a lymphocyte proliferation assay & when analysed by Capillary GC/MS its contents were found be monoterpenes (13.1%), sesquiterpenes(1%),and diterpenes (42.5%). Mikhaeil 2003